Differential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2α phosphorylation

Challenges in Surveillance for Chikungunya Virus (CHIKV) Infection

Introduction CHIKV is transmitted by mosquitoes and often occurs in large outbreaks with high attack rates. Common symptoms (which can be severe and disabling) include fever, joint pain/swelling, headache, muscle pain and rash. In December 2013, the World Health Organization reported local CHIKV transmission in the Caribbean. In July 2014, the first locally-acquired case in the continental U.S....

Why Can We See a Local Spread of Chikungunya Virus (CHIKV) Infection?

Nonhuman Primate Models of Chikungunya Virus Infection and Disease (CHIKV NHP Model)

Chikungunya virus (CHIKV) is a positive-sense RNA virus transmitted by Aedes mosquitoes. CHIKV is a reemerging Alphavirus that causes acute febrile illness and severe and debilitating polyarthralgia of the peripheral joints. Huge epidemics and the rapid spread of CHIKV seen in India and the Indian Ocean region established CHIKV as a global health concern. This concern was further solidified by ...

Unfolded protein response in hepatitis C virus infection

Hepatitis C virus (HCV) is a single-stranded, positive-sense RNA virus of clinical importance. The virus establishes a chronic infection and can progress from chronic hepatitis, steatosis to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The mechanisms of viral persistence and pathogenesis are poorly understood. Recently the unfolded protein response (UPR), a cellular homeostatic resp...

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes chikungunya fever

Development of a Pseudotyped Lentiviral Vector–Based Neutralization Assay for 1 Chikungunya Virus Infection 2 3 Running Title: CHIKV-pseudotyped lentiviral vector–based NT assay 4 5 Natsuko Kishishita, Naokazu Takeda, Atchareeya Anuegoonpipat, and Surapee 6 Anantapreecha 7 8 Thailand-Japan Research Collaboration Center on Emerging and Reemerging Infections 9 (RCC-ERI), Nonthaburi, Thailand 10 R...